IDPH Updates Interim Guidance on MIS-C

July 2, 2020

The Illinois Dept. of Public Health today issued updated interim guidance to ensure clinicians are aware of current guidance regarding Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19), including the case definition and guidance on reporting to local health departments.

IDPH says essential actions on MIS-C include:

  • All healthcare providers should maintain a high index of suspicion for MIS-C.   
  • Suspected cases of MIS-C should be referred immediately to a tertiary care center with a pediatric intensive care unit (PICU).   
  • Tertiary care centers are asked to consider a collaborative approach in the management of these patients by convening a multispecialty committee (comprised of pediatric critical care, cardiology, hematology, infectious disease, and rheumatology/immunology) that provides coordinated clinical care guidance for each patient while (1) confirming patients meet the case definition, and (2) ensuring that appropriate diagnostic and treatment resources are readily available for this patient population.   
  • Hospital infection preventionists should be notified immediately upon recognition of patients meeting case definition to initiate public health reporting.

The IDPH guidance also covers reporting requirements, including:

  • Health care providers and laboratories are required by the Control of Communicable Disease Code to report suspected or known MIS-C associated with COVID-19 cases to the local health department.   
  • When an MIS-C associated with COVID-19 case is suspected to be or is known to be (laboratory-confirmed case) the cause of death in an individual, this should be reported to the local health department.   
  • Hospitals must submit pre-defined data elements on MIS-C patients through Illinois’ National Electronic Disease Surveillance System (I-NEDSS). NOTE: Electronic laboratory reporting alone will not suffice for this syndrome.